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Diet, Longevity Medicine, Sleep

The Glymphatic System: New Discoveries On Sleep And The Aging Of The Brain

The Glymphatic System: New Discoveries On Sleep And The Aging Of The Brain

Our Brain’s Newly Discovered Lymphatic System

Somehow, despite thousands of neurosurgeries and thousands of brain images, we missed it: there is a system of drainage vessels buried under the dura mater, the leather-like outer layer that surrounds the brain. It was theorized to exist in 2015 and definitively found in 2017. The glymphatic system is the lymphatic system of the brain, responsible for removing pathological proteins, including amyloid, that build up during the course of the day. The glymphatic system functions primarily during sleep, and mainly during the deeper phases of sleep, medically termed “N3” sleep.  As we age, our other two systems of brain “cleaning” slow down, our sleep quality deteriorates, and metabolic debris, along with amyloid, begins to stack up… another challenge of aging. Read more

April 1, 2022/by Jay Lombard, DO
https://www.hvfm.org/wp-content/uploads/2022/04/brain-gbcdd639a2_1920-copy.jpg 500 1400 Jay Lombard, DO https://www.hvfm.org/wp-content/uploads/2020/12/hvfmlogo_large-1030x139.png Jay Lombard, DO2022-04-01 14:23:442022-04-01 14:27:02The Glymphatic System: New Discoveries On Sleep And The Aging Of The Brain
Diet, Longevity Medicine

URIC ACID: Much Bigger Than A Big Toe Problem!

Uric Acid Crystals

A Malady Of Kings 

Uric acid is probably most famous for causing gout, an extremely painful, acute arthritis typically in the big toe but occasionally in other joints. However, new research over the last 10 years has exposed this circulating purine breakdown product as a metabolite that warrants our attention and concern, and not just for the health of our toes! There is accumulating evidence that uric acid directly causes fat accumulation, predicts the development of diabetes, and plays a major role in the appearance of metabolic syndrome (hypertension, diabetes, high lipids, abdominal fat deposits). All this can happen with or without a red-hot toe.  Read more

March 28, 2022/by Sheryl Leventhal, MD
https://www.hvfm.org/wp-content/uploads/2022/03/towfiqu-barbhuiya-J6g_szOtMF4-unsplash-belly-fat-composite.jpg 500 1400 Sheryl Leventhal, MD https://www.hvfm.org/wp-content/uploads/2020/12/hvfmlogo_large-1030x139.png Sheryl Leventhal, MD2022-03-28 13:15:552022-03-29 13:49:47URIC ACID: Much Bigger Than A Big Toe Problem!
Diet, Longevity Medicine

Ode to Dark Chocolate: The Health Benefits of Dark Chocolate for Aging Skin

Health Benefits of Dark Chocolate

Dark Chocolate’s Health Benefits Include Skin Health

No website or blog on longevity medicine would be complete without a piece on aging skin, which includes UV-induced photodamage, loss of dermal matrix, and wrinkles. Of course, hormones, lifestyle, and sun exposure play a large role in how our skin ages, and we are covering those topics in other pieces. But I recently came across a series of articles highlighting the large beneficial effect of one of my favorite foods: dark chocolate! Read more

October 21, 2021/by Sheryl Leventhal, MD
https://www.hvfm.org/wp-content/uploads/2021/10/dark-gd47cd1016_1920-cropped.jpg 500 1400 Sheryl Leventhal, MD https://www.hvfm.org/wp-content/uploads/2020/12/hvfmlogo_large-1030x139.png Sheryl Leventhal, MD2021-10-21 18:19:142022-03-28 13:18:48Ode to Dark Chocolate: The Health Benefits of Dark Chocolate for Aging Skin
Diet, Exercise, Immune System, Lifestyle, Longevity Medicine

Your Immune System Reboot: Diet & Lifestyle

Your Immune System Reboot

When the coronavirus SARS-co-v2, a devastating communicable disease, descended upon the global population in December 2019, it became clear early on that there was a wide spectrum of illness, ranging from almost nothing to diarrhea, severe pneumonia, stroke, and death. By May of 2020, it became even more clear that there are particular conditions (“comorbidities”) that markedly increase the disease severity and death rate, and that these conditions had in common an immune system dysfunction with the shared characteristic of chronic inflammation. We have learned that people with chronic inflammation have higher levels of furin and that furin acts as a facilitator to allow better binding of the viral spike protein to our ACE2 receptors. Harboring chronic inflammation turns us into something like Velcro, attracting more virus, secreting more furin, and allowing more severe disease states to evolve.  Read more

February 16, 2021/by Sheryl Leventhal, MD
https://www.hvfm.org/wp-content/uploads/2021/02/chuttersnap-zYvuRX4kIWE-unsplash-crop.jpg 534 1429 Sheryl Leventhal, MD https://www.hvfm.org/wp-content/uploads/2020/12/hvfmlogo_large-1030x139.png Sheryl Leventhal, MD2021-02-16 17:28:322021-08-05 14:34:34Your Immune System Reboot: Diet & Lifestyle
Diet, Longevity Medicine

Merlot Meets TMAO!

Merlot Meets TMAO - Longevity Medicine

This is a story that starts with some negative publicity for meat, fish, and eggs, but has a better ending, although much controversy remains and science is still working out pathways. Fortunately for us, all sides agree that wine and high-quality olive oil, as well as other high polyphenol foods, emerge as “fixers” of this newly discovered risk factor.

In 2013 there was renewed interest in the compound TMAO (trimethylamine N-oxide), which our bodies (specifically our gut bacteria and liver) make from dietary choline, carnitine, and lecithin. Those primary ingredients are enriched in meat, fish, and eggs in particular. Fish contain the highest amount of preformed TMAO of any food group. Several papers found associations between higher plasma levels of TMAO and increased risk for cardiovascular disease (heart attack or stroke) between 2013 and 2019. The papers caused a small panic in the paleo and carnivore camps, which had been advocating avoidance of grains, beans, and fruit due to the potential inflammatory effects of lectins, sugars, and processing. Also, it was difficult to square this new TMAO effect (risk) with the consistent and strong protective effects of frequent fish consumption. Other studies were published that did not always confirm the connection. The dietary ingredients (or sometimes they were given as supplements) were carnitine, choline, and lecithin.  They were converted by the microbes to TMA and then by the liver to TMAO.

Read more

December 14, 2020/by Sheryl Leventhal, MD
https://www.hvfm.org/wp-content/uploads/2020/12/Merlot-Meets-TMAO2.jpg 650 1757 Sheryl Leventhal, MD https://www.hvfm.org/wp-content/uploads/2020/12/hvfmlogo_large-1030x139.png Sheryl Leventhal, MD2020-12-14 20:08:522021-08-10 13:56:40Merlot Meets TMAO!

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Longevity Medicine is the future of your health! Watch the HVFM blog for the latest developments in all areas longevity – genomics, diet, technology, lifestyle, and more.

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